Learning HCR with Keren Yam from Lupiañez Lab

real lab team October 21, 2025 December 19, 2025

We are excited to share that we are currently training with Keren to master In situ Hybridization Chain Reaction (HCR) 🔬.

What is HCR? HCR is a in situ hybridization method that allows to visualize the spatial distribution of gene expression directly within intact tissues. Unlike traditional methods, HCR uses a chain reaction of hybridization events to amplify the signal, providing high sensitivity and clear localization of target transcripts.

When you tell the sample: Everything better go right or else — When you tell the sample: ‘Everything better go right… or else!

Optimizing steps while enjoying the process

Here you can see one of our first images 🎉!

Samples from ten years ago and Sox9 still shining bright in the tail — Samples from ten years ago and *Sox9* still shining bright in the tail

Stay tuned for updates and images from this exciting work!